The scenario was based on an unidentified short story by Thomas Edgelow, published in Live Stories Magazine. Principal photography was completed at Universal Studios in Universal City, CA, as stated in the 27 January 1917 Moving Picture Weekly. That day’s issue of Motion Picture News revealed that J. Warren Kerrigan had initially been cast as “Raymond Van Seer.” After he left the employ of Bluebird Photoplays, Inc., Harrison Ford took over the role, necessitating the re-shooting of much of the film.
       The Mysterious Mrs. M was released on 5 February 1917, preceded by a 22 January 1917 premiere at the Rialto Theatre in New York City.
       Later that year, the 18 August 1917 Motography recounted a publicity stunt concocted by H. J. Thatcher, manager of the Strand Theatre in Salina, KS, with the assistance of two local businessmen. Days before the film’s Salina debut, a woman identifying herself as “Mrs. M” registered at the best hotel in town, and purchased a car emblazoned with the film’s title. She was seen around town for the next two days wearing a half-mask, while rumors spread that she was a famous clairvoyant. On the third day, she stole a diamond ring from a jewelry store, with Thatcher driving the getaway car. The jeweler declined to prosecute, claiming that she paid for the ring afterward. “Mrs. M” made her next appearance at the Strand and requested assistance from Thatcher upon finding none of the available seats to her liking. When Thatcher demanded to know the disruptive woman’s name, she proclaimed, “I’m the Mysterious Mrs. M,” just as an advertisement for the film appeared on the screen. The feature opened the following day to record attendance.
       According to the Library of Congress American Silent Feature Film Survival Database, this film is extant.