The Pythons, professional basketball team of Pittsburgh, Pennsylvania, struggles through a dismal season of ten wins and twenty-six losses. Attendance is at an all-time low and the players beg to be traded. After another humiliating defeat, Lucian Tucker, the most vocal member of the disgruntled squad leads a walkout, which also involves Coach “Jock” Delaney. However, Moses Guthrie, the Pythons star player, remains behind in the locker room, bemoaning his prolonged slump. When Tyrone Millman, the team’s fourteen-year-old precocious water boy, tries to offer encouragement, Moses is grateful and reveals that as a Pisces star sign, he needs a boost at times. The mention of astrology triggers an idea with Tyrone, and he spends the evening obsessively studying the zodiac. Later, he makes an appointment with quirky astrologist, Mona Mondieu, and asks if she will chart the star signs of a basketball team. Initially, she hesitates, but accepts after Tyrone mentions that every player will belong to the Pisces sign. Next, the boy approaches Moses, proposing that the Pythons franchise should draft new players, based on their astrological compatibility with Moses. The basketball star is skeptical, but soon finds himself standing by Tyrone as the boy presents the idea to team owner, H. S. Tilson. As a childlike man whose interests are motivated by amusement rather than money, H. S. embraces Tyrone’s suggestion, despite the objections of team manager Wally Cantrell. Meanwhile, businessman Halsey Tilson, H. S.’s devious older brother, reads the headline, “Pythons Coach & Team Walk” and complains that the basketball scandal will harm the Tilson name. However, Halsey primarily resents that H. S. was his father’s favorite son, who inherited $80 million and the family estate. At the Pittsburgh Civic Arena, a circus atmosphere takes places as a variety of players stand in line for open tryouts. Prospective candidates are first requested to write their birth dates on the application form. During the mayhem, Cantrell promotes assistant coach George Brockington to head coach. Later, in the locker room, Harry, the trainer, takes roll call for the new team. The eccentric group of players includes Horace “Setshot” Bufford, who is short but displays a gift for shooting, a former outstanding college prospect named “Driftwood,” identical twins Benny and Kenny Rae, rapper Jackhammer Washington and the Reverend Grady Jackson, who has a flair for passing the ball. Five days later, the revamped team faces Detroit for their first game, and Tyrone, who appears more capable than the inept Brockington, gives the players a motivational talk prior to the game. Revealing that the squad shares the Pisces sign, he explains that they are astrologically compatible and can accomplish anything. When the eccentric-looking Pythons take the court, the hometown crowd and the opposing team jeer, but Tyrone smiles with confidence. Although their playing style is unorthodox, the team surprises everyone by playing spectacular basketball. For the next twelve games, the Pythons continue the winning streak, and Moses regains his championship form as the top scorer. In the locker room prior to an important game against New York, H. S. makes an announcement that the franchise name will change to the Pittsburgh Pisces and presents a flashy, new uniform. After Tyrone introduces Mona to the players, she advises them on their one-on-one matchups with New York based on astrology and warns them that due to a shift in the cosmos, they will face more challenges tonight. During the first half, the Pisces play indecisively and trail by fifteen points at halftime. In the locker room, Mona advises the team to take advantage of Setshot’s free throw skills to make up the deficit. Although the undersized Setshot is battered while drawing fouls from opposing players, the strategy works, and the Pisces clinch a dramatic win by one point. As the “Cinderella” team progresses toward the championship series, they rely on Mona’s guidance rather than Brockington. Meanwhile, the city of Pittsburgh is consumed with “fish fever.” After beating Chicago and Washington in the playoffs, the Pisces face Los Angeles in the finals. The series is tied, as the two teams meet in Pittsburgh for the deciding seventh game. Meanwhile, Halsey, who is desperate to spoil his brother’s success, undermines the Pisces’ astrological strategy by kidnapping Mona. In a dramatic introduction, the retractable roof opens and the hometown Pisces enter the arena in a hot-air balloon basket shaped like a fish. However, Tyrone and the players are worried as Mona’s courtside seat remains empty. Los Angeles, led by star players like Kareem Abdul-Jabbar, take an early lead while Moses faces a challenging matchup from his former hot-tempered teammate, Lucien. In Mona’s absence, Tyrone studies the astrological forecast and realizes that they must stall the game until midnight when the outlook will be better for the Pisces. Meanwhile, Mona escapes from her kidnappers, steals their car and speeds to the arena. During halftime, Tyrone tries to prolong the entertainment show and then disrupts the start of the second period by sneaking helium-filled basketballs into the game. As the competition finally gets underway again, the Pisces struggle and the chances of the game stretching until midnight appear unlikely. With the team trailing by ten points, Moses delivers a motivational speech during a timeout, reminding his teammates that astrology was only a guide; they reached the finals based on their talent. The players rise from the bench inspired and initiate a scoring surge. Mona then arrives courtside, and the crowd chants her name. Although she confirms the calculations that the Pisces are not favored to win tonight, Tyrone feels confident as long as the players are unaware of the dire forecast. Moses excites the crowd in a display of awe-inspiring basketball, but Los Angeles still holds a one-point lead in the final seconds. During a jump ball, the Reverend taps the basketball to Moses who scores and delivers the Pisces to a 105 to 104 victory. On the court, the Pittsburgh fans and their unlikely comeback team erupt in celebration.