On a flight to Los Angeles, California, British actress Diana Barrie watches herself on the in-flight movie in the role for which she has received an Academy Award nomination. She expresses her nervousness about the upcoming Oscar ceremony to her husband, Sidney Cochran, as the plane lands. Elsewhere, on a Los Angeles freeway, Dr. Willis Panama and Dr. Chauncey Gump, physicians from Chicago, Illinois, vacationing together with their wives Bettina and Lola, bicker with each other constantly as their rental car first breaks down, then collides with two other vehicles. As Diana and Sidney check into the Beverly Hills Hotel, Hannah Warren paces her room in the hotel while waiting to meet with her ex-husband, Bill Warren. When he arrives, they note that it has been nine years since they saw each other, then they leave to keep the lunch reservation he made. At the Los Angeles airport, Harry Michaels picks up his brother, Marvin Michaels, who has come to town to attend Harry’s son’s bar mitzvah. Marvin explains that he and his wife Millie always fly separately, so she will arrive the next morning. Marvin notices that Harry still ogles and wants to proposition every beautiful woman he sees. Harry drops Marvin off at the Beverly Hills Hotel and they arrange to meet for dinner later. Hannah and Bill reminisce over lunch and later at his beachfront home. She is an editor for Newsweek magazine and dating a writer for the Washington Post. He is a former journalist, now working as a screenwriter, and contemplating marrying his girlfriend. Then they discuss the real reason Hannah has flown to Los Angeles: their seventeen-year old daughter, Jenny, unhappy living with her mother in New York, ran away to stay with her father and wants to spend the next year with him in Los Angeles. Hannah doesn’t want her daughter living in southern California but she is nervous about seeing Jenny and getting her to return to New York. Back at the hotel, Diana continues fretting over the likelihood of winning the Academy Award and exchanges witty banter with Sidney. Later, she has a couple of drinks to calm her nerves as she gets dressed for the awards ceremony. As Hannah and Bill return to Hannah's hotel room, Jenny calls and informs her parents that she will abide by whatever decision they make. Hannah announces to Bill that Jenny will return to New York with her. Bill is disappointed but trusts Hannah’s instincts. When Hannah expresses how afraid she is of losing Jenny, Bill remarks that he has never seen his ex-wife so vulnerable. Then Hannah says Jenny can stay with Bill in Los Angeles, but only for six months. Hannah watches Jenny drive off with Bill. At the hotel’s front desk, the doctors learn there is a reservation for Willis but not for Chauncey. The hotel has no extra rooms because it is Academy Award week. The only thing available is a small single room undergoing repairs. Chauncey agrees to take it. Later, Willis tells Chauncey that he has made a dinner reservation at a Japanese restaurant and booked them a tennis court for a doubles game the next day. While the Gumps struggle to get ready in their tiny room, Chauncey complains about having to eat Japanese food. As Willis and Bettina wait for their friends in the lobby, Willis complains that Chauncey is always late. When the two couples finally gather at the hotel’s front door, the doctors argue about who will drive to the restaurant, until Bettina insists she will drive. On the way to the Academy Awards, a nervous Diana begs Sidney to be nice to her and wish her luck. He reminds her how talented she is and gives her a kiss. They exit the limousine and greet the crowd outside the venue. Elsewhere, paramedics arrive at a collision in which a car is on top of the one Bettina is driving. While a policeman questions her, Chauncey insists to the officer that his legs are paralyzed from sitting down at the Japanese restaurant. After the Academy Awards ceremony, Diana observes Sidney speaking with an attractive young man. Drunk, she takes her disappointment about losing the Oscar out on her husband. At the hotel, as Harry drops his brother off after dinner, Harry teases Marvin that “the night is not over yet.” Marvin goes to his room and finds that Harry has hired a hooker, Bunny, to entertain him. Later, Chauncey wakes up in the middle of the night, sick from the Japanese food. Lola calls Willis and insists he tend to Chauncey. Willis angrily acquiesces. Back in their hotel room, Diana jealously insists that Sidney was flirting with the young man that she saw him speaking with earlier. Sidney asks her why they cannot lie to each other about the nature of their relationship the same way they lie to everyone else about it. He reminds her that he has never hidden who he is. Diana asks why Sidney doesn’t love her anymore. He insists he never stopped loving her. She says his kind of love doesn’t do her any good, then begs him to “screw” her before immediately apologizing. She loves him but she doesn’t understand why he stays with her when he could share the company of other gay men exclusively. He explains he enjoys his proximity to her minor celebrity and tells her he loves her more than any woman he’s ever known. They acknowledge they have fun together, then share a kiss. She comes to bed and they make love. The next morning, Marvin wakes up to find himself in bed with Bunny. He tries to get her up and out of the room but she has passed out after drinking a bottle of tequila. Calling the front desk, Marvin learns that his wife, Millie, has just arrived and is on her way to his room. He tries to keep Millie from discovering the nude, unconscious hooker in his bed but finally reveals his indiscretion. Incensed, Millie leaves. Elsewhere at the hotel, Willis, Bettina, Chauncey and Lola play doubles tennis. Bettina accidentally smashes her racket on Willis’ head, loses her balance and injures her ankle as she falls. Lola stumbles over a basket of tennis balls trying to come to Bettina’s aid and Chauncey trips over the net trying to help Lola. Outside the Michaels’ room, Millie hurries away as Marvin tries to explain his infidelity. At first, Millie doesn’t see how she can attend the bar mitzvah knowing Harry paid for Marvin’s hooker, then she decides to forgive Marvin and forget it ever happened. She also plans to spend all of his money. The Panamas and the Gumps return to the Panamas’ room to care for Bettina’s ankle. Lola breaks a bottle of perfume in the bathroom, then cuts her finger on one of the glass shards. While they tend to Lola, Bettina trips and falls through the room’s French doors, breaking the panes of glass. Then Lola bangs her head on the door of the medicine cabinet while rinsing off her bleeding finger and passes out. Willis goes to the bathroom to soak a wet towel for her, but steps on the broken glass. Willis and Chauncey put both women on the bed then start fighting each other, damaging the room in the process. After shopping in the hotel boutique, Millie returns to the hotel room. Marvin tries to embrace her but she wants no signs of affection from him in front of the still-unconscious hooker on their bed. In the Panamas’ room, Chauncey swears it has been the worst trip ever and Willis tries to force Chauncey to say it is the best time they ever had and that the Gumps will love going on vacation with the Panamas again. In front of the hotel, the cab that the Michaels were going to take to the bar mitzvah has been given to Bunny, who is awake and fully dressed. She generously allows them to ride with her to their destination. At the airport, Hannah is surprised to see Jenny, who has come to say good-bye and thank her mother for letting her stay with Bill. In another part of the airport, the Panamas and the Gumps, who are bruised and covered in bandages, limp towards their flight. As Diana and Sidney’s plane takes off, they learn that the in-flight movie is the same as on their flight to Los Angeles and Diana begs Sidney to get them off the plane.