According to the 20 November 1915 Motion Picture News, "All Selig cameramen, many of the directors, and about three hundred people were at San Pedro Saturday to take part in scenes for My Neighbor's Wife, being directed by Colin Campbell. A superstructure of a sea-going vessel showing the saloon, staterooms, stokers' holds and docks of the ship, had been previously constructed and was used in these scenes which terminated with the vessel capsizing."
       The 29 January 1916 Motion Picture News reported that Selig enacted a "true-to-life shipwreck in which an ocean-going liner strikes a derelict and thousands of men, woman and children plunge headlong in their night clothing from the various decks into the water below." The cost of this scene was $25,000 (the 15 January 1916 Moving Picture World said it was $50,000). Accompanied by a photograph showing the action, the item stated further that "there is a battle to the death between a royal Bengal tiger and a monster leopard defending its young, and a desperate conflict between white hunters and a horde of African tribesmen."
       Exteriors were shot at the Selig Jungle Zoo in Los Angeles, and the zoo's animals were used extensively. Animal trainer Princess Olga Celeste, "the leopard lady" of the Selig Jungle Zoo, told the 17 June 1916 Motography, "The animals gave us much trouble in the play Thou Shalt Not Covet. We worked for days on some scenes....There is always danger in an animal act."
       The film's subtitles, in the form of entries in the protagonist's diary, were written in the first person, according to reviewer William C. Esty in the 29 January 1916 Motion Picture News.
       The title came from the Tenth Commandment, in Exodus 20:17, which said: "Thou shalt not covet thy neighbor's house. Thou shalt not covet thy neighbor's wife, or his male or female servant, his ox or donkey, or anything that belongs to your neighbor."
       According to the Library of Congress American Silent Feature Film Survival Database, this film is extant.