The 5 June 1915 Motion Picture News reported, "Neither money nor care has been spared to make the present screen version" of Fox Film's The Two Orphans. "Every one of the massive sets used in the production has been built up with scrupulous care and minute attention to detail, such scenes, for instance, as the streets of Paris, showing the arrival of the two orphans, and the front of Notre Dame Cathedral being built to the exact scale of the original subjects. The prison of La Saltpetriere alone cost $10,000 to build and required in its construction ten tons of masonry work, three miles of canvas, a dozen barrels of nails, four tons of paint, and the services of one hundred carpenters, twenty painters, ten stone masons and a score of electricians." The Fox studios were in Fort Lee, NJ.
       The 10 September 1915 Variety claimed, "Many of the scenes were taken in Montreal [Canada]. That city may be Mr. Brenon's idea of America's Paris, where the locale is supposed to be, but anyway Montreal did its work. One or two scenes in a snow storm were pretty in effect." Variety also named several well-known actors who made only cameo appearances, including Stella Hammerstein, Irene Lee, Edna Hunter, and Ben Graham.
       The 13 August 1915 Variety announced that filming was complete. Two weeks later, the 28 August 1915 Motion Picture News noted that the movie had cost "more than $300,000."
       The Two Orphans was William Fox's first release under his company's "one-a-week policy," which promised fifty-two new motion pictures a year from his studios, according to a full-page advertisement in the 4 September 1915 Motion Picture News.
       Actress Kate Claxton, who had introduced the character of "Louise" on the New York stage many years earlier, sued in Federal District Court to stop Fox Film Corp. from releasing The Two Orphans, claiming that it had infringed upon her copyright of an English translation of the 1875 French play by Adolphe-Philippe D'Ennery and Eugène Cormon. The 12 February 1916 New York Clipper reported that Fox settled with Claxton for $2,500. Selig released a three-reel version of Claxton's version of the play in June 1916.
       Fox reissued The Two Orphans in the summer of 1918.
       The then-familiar story had previously been filmed, twice, in 1907, by Selig Polyscope and Pathé Frères (see entries). D. W. Griffith produced a film based on the same play in 1922, but retitled the story Orphans of the Storm (see entry), which starred the Gish sisters, Dorothy and Lillian. That film is extant.
       The National Film Preservation Board (NFPB) included Fox's The Two Orphans on its list of Lost U.S. Silent Feature Films as of October 2019.