A list of releases in the 19 May 1917 Motography identifies Alien Blood as one of the Balboa Amusement Producing Co's Fortune Photoplays, preceding Zollenstein and Phantom Shotgun (see enties). As such, it would have been part of a series of weekly four-reel features, comprised of adaptations of stories that appeared in various Street and Smith publications, including Popular, People's, Smith's, Top Notch Detective Stories, and Ainslee's magazines. Filming would have been done at the Horkheimer Brothers' Balboa Studio in Long Beach, California. Other Fortune films included The Inspirations of Harry Larrabee (which also starred Clifford Gray and Winnifred Greenwood), Mentioned in Confidence, The Devil's Bait, The Yellow Bullet, Vengeance of the Dead, Zollenstein, The Mainspring, and Clean Gun (all 1917, see entries), as listed in the 17 March 1917 issues of Motion Picture News and Moving Picture World. The latter three were not released until Balboa began a second four-reel series called Falcon Features in August 1917, after the Fortune Photoplay series prematurely ended two months earlier.
       Alien Blood opened as a Fortune Photoplay on 16 April 1917 in Bemidji, MN, supported by a "Ham and Bud comedy," according to that day's Bemidji Daily Pioneer. It later opened as an "extra" attraction with Charlie Chaplin's The Immigrant at the Moore's Garden Theater in Washington, D.C. the first week in July 1917, according to an advertisement and press item in the 1 July 1917 and 3 July 1917 editions of Washington Post. The press item stated: "Miss Winnifred Greenwood scores a triumph over her enemies and succeeds in wiping away a barrier of blood."
Alien Blood was not mentioned in any of the early reports about Fortune Photoplays and was not reviewed. It may have had a limited release. One contemporary publication incorrectly referred to this film as a Méliès production. Available contemporary sources identified the cameraman only as "Garnett."
       According to the Library of Congress American Silent Feature Film Survival Database, this film is extant.