A full-page Essanay/George Kleine System advertisement in the trade magazines, including the 18 May 1918 Exhibitors Herald, called Mary MacLane the "Most Talked of Woman Today....Everyone is thrilling over her recent disappearance from a Chicago hotel and the finding of her burning love letters—published in newspapers all over the United States. You can pack your house by showing this eccentric genius in Men Who Have Made Love to Me, a picture that bares her very soul." MacLane had scandalized the literary world sixteen years earlier, in 1902, when she published her first book, The Story of Mary MacLane, while still in her late teens. With its confessions of disparate sexual dalliances, including bisexual relationships, the book reportedly sold over 100,000 copies during its first months, and eventually became popular all over the world.
       The 6 October 1917 Motography revealed that the "authoress" was "writing her own scenario at the Essanay studios." In her statement to the press MacLane said, "I have the passionate, sensuous gray eyes of the weary courtesan and the virginal pink lips of the cloistered nun. I have a slim young body and it was my vanity that saved me from many a slip between the cup and the lip....I have had loves to which I have given my heart's blood by the gallon."
       Essanay built elaborate and expensive sets for the movie, the 27 October 1917 Motion Picture News reported. "One set represents an apartment in a high class hotel. It contains eight rooms, arranged so that glimpses of all other seven rooms are had when the camera is trained on the spacious library. Where the average set can be created in a few hours, Director Arthur Berthelet consumed several weeks in completing the apartment. Thousands of dollars' worth of furnishings and pictures are used for this set. Another interesting scene is staged in the sunken gardens of a Summer resort hotel. It required several florists to supply the palms, ferns and flowers for this scene, which was built on Essanay's big outdoor stage."
       Mary MacLane's wardrobe was "an amazing array of evening gowns, traveling suits, riding habits, lounging robes, boudoir outfits, motoring costumes—in fact, everything, including bathing suits and gymnasium togs," according to the 3 November 1917 Moving Picture World. "Much of the wardrobe was imported."
       The 8 December 1917 Motography announced that MacLane "has completed her seven-reel vampire photoplay, Men Who Have Made Love to Me."
       According to the 29 December 1917 Motion Picture News, Essanay "art directors are engaged in designing the subtitle scheme of Mary MacLane's first and only screen presentation....The celluloid on some of these subtitles went through the camera six times to obtain the desired effect. These particular ones show Miss MacLane as she sits at her library desk, relating the story of her 'six piquant love affairs—each damnably real.' The smoke of her cigarette curls in and out through the spoken lines at Miss MacLane's elbow. It is deviation and an artistic improvement on the 'spoken subtitle' idea."
       Mary MacLane's byline appeared on a two-page, photo-illustrated article in the January 1918 Photoplay. According to an introduction, the Butte, Montana, native "has become a movie star. The same MacLane who at the age of seventeen made the world at large sit up and take notice with The Story of Mary MacLane [1902] in which she registered some astonishingly frank truths about herself and her emotions." (Her original title was I Await the Devil's Coming, which was later reinstated and remains so today in ongoing editions.) The book was followed years later by I, Mary MacLane, "a matured continuation of [her] introspective analysis," which "is being immortalized upon the screen at the Essanay Studio, in Chicago." She assured the readers, "I may look like a vampire, but I continue to feel singularly unlike one. I am a fan and not a critic, and my secret hankering is to be an extra person, ad-lib-ing in a mob." A Motography writer agreed about the first part: "It might be called a sparkling comedy-drama with a vampire playing the lead, but with the fangs extracted."
       The scenarist may have been Edward T. Lowe, Jr., who was a staff writer for Essanay.
       Men Who Have Made Love to Me premiered in Chicago at the Band Box Theatre on 3 February, 1918, the Exhibitors Herald wrote three weeks later.
       The film was released as a six-reeler.
       The censor, police chief, and appeal board of Kansas City, MO, all rejected the picture and enjoined the Garden Theatre from screening it, the 27 February 1918 Exhibitors Herald reported. Manager W. H. Quigley filed an injunction suit against them all in the local circuit court.
       The National Film Preservation Board (NFPB) included this film on its list of Lost U.S. Silent Feature Films as of February 2021.