The 11 Nov 1960 LAT announced an upcoming production based on the ancient Greek legend, to be produced in Italy by talent agent Sam Jaffe and movie industry veteran Samuel Marx. A deal had been recently completed with Metro-Goldwyn-Mayer, Inc. (MGM) for financing and distribution. Although casting was to take place in Hollywood, CA, stardom was not "to take precedence over the historic appeal" of the characters. Two previous film versions were made in 1908 and 1914 (see entries). As noted in the 21 Nov 1960 DV, Jaffe and Marx opened a New York City office the following month. At the time of the article, Jaffe was in London, England, coordinating the start of production. A news item in the 2 Dec 1960 DV reported that the team consulted with the ancient history department at University of Southern California (USC) regarding costumes and architecture. The story was set in Syracuse, Sicily, in 400 B.C.
       According to the 12 Dec 1960 DV, Bantam Books was in negotiations to publish a novelization of the screenplay. Marx and screenwriter Barry Oringer, who collaborated on the scenario, would also write the book.
       Although the 23 Dec 1960 LAT reported that the producers hoped to cast James Garner and John Gavin in the title roles, they eventually agreed on Guy Williams and Don Burnett. As of 16 Jan 1961, casting was underway in London, as noted in that day's DV. The 5 Jul 1961 Var also included Tommy Garvasi in the cast. The 1 Jun 1961 DV announced the scheduled start of principal photography later that month at Cinecitta Studios in Rome, Italy. However, production was delayed until 18 Sep 1961, as confirmed by a 6 Oct 1961 DV production chart.
       Jaffe later told the 3 Dec 1961 LAT that he had no choice but to film in Rome, as costs in the U.S. would have reached approximately $2 million, which MGM would not have approved. In Rome, he was able to make the picture for "less than half that amount," while maintaining high production values. The recent completion of photography was announced in the 15 Dec 1961 DV.
       Damon and Pythias opened 5 Sep 1962 in New York City, on a double bill with Tarzan Goes to India. Openings in Los Angeles, CA, followed on 28 Nov 1962. Reviews were lukewarm to positive. The picture also shared bills with The Savage Guns (1962, see entry) in Kansas City, MO (19 Dec 1962 Var); and It Happened at the World's Fair (1963, see entry) in Detroit, MI (5 Jun 1963 Var).
       Opened in Rome in Sep 1962 as Il tiranno di Siracusa; running time: 102 min. Alternative Italian title: Damone e Pitias. Sources conflict in crediting the role of Mereka.