I Love You, Alice B. Toklas! marked the feature film writing and producing debut of Paul Mazurksy and Larry Tucker. It was announced as an upcoming Warner Bros.—Seven Arts, Inc. production in the 23 Aug 1967 Var, which cited a budget of $2.7 million. Later items in the 15 Nov 1967 Var and 24 Nov 1967 LAT stated that the film would cost $3 million.
       Principal photography began on 14 Nov 1967 in and around Los Angeles, CA, at locations including Venice Beach, the Leo Carrillo State Beach, the “Sunset Strip” on Sunset Boulevard, and sites near the intersection of Fairfax Avenue and Beverly Boulevard. Filming also took place on the Warner Bros.—Seven Arts studio lot in Burbank, CA. A fifty-five-day shooting schedule was planned.
       On 29 Nov 1967, Var announced that Rabbi Harry Horwitz would play a rabbi, using the stage name “Hal Horton.” Twin cantors Samuel and Bernard Kelemer were also hired to play cantors, according to a 6 Dec 1967 Var brief. Eleven family members of actor Joe Dominguez, who played “Grandfather Rodriguez,” were said to be cast in the film, including Julian Rivero, Margarita Martin , Tony Davis, Yolanda Alonzo, Marian Valjalo, Glenn Hughes, Alma Beltran, Felipe Turich, and Alegra Varron, as stated in the 14 Dec 1967 DV. Various DV items published between 3 Jan 1968 and 15 Feb 1968 named Erika Von Kessler, Larry Brightman, Elliot Ingber, Arlene Stephen, and KNXT newscaster Clete Roberts as cast members.
       Choreographer David Ahdar was hired to stage a dance sequence, the 28 Dec 1967 DV reported.
       Leading actor Peter Sellers was repeatedly late to set, according to an 8 Jan 1968 LAT article. The reduced filming time necessitated the use of three cameras so that “one minute of usable rushes per day” could be completed. Sellers was also rumored to have “exploded” on set when he saw someone wearing green – the color of a car involved in his recent automobile accident – and, in another incident, he had threatened to abandon the picture unless the entire crew was replaced. Nevertheless, Sellers remained with the project, and when it was released in Los Angeles on 29 Aug 1968, his performance received high praise in the 28 Aug 1968 Var and 29 Aug 1968 LAT reviews.
       After four months in release, I Love You, Alice B. Toklas! had grossed $1.1 million in film rentals, as stated in a box-office chart in the 8 Jan 1969 Var.
       Leigh Taylor-Young, who made her motion picture acting debut in the film, was nominated for a Golden Globe Award for New Star of the Year – Actress.