Where Angels Go…Trouble Follows! is a sequel to the 1966 film, The Trouble with Angels (see entry), which had been “enormously successful,” as stated in a 16 Jun 1967 LAT article. Actresses Rosalind Russell, Binnie Barnes, Mary Wickes, Dolores Sutton, and Barbara Hunter signed on to reprise their roles, and the 17 May 1967 DV noted that, as with the first film, William Frye would produce for Columbia Pictures. The following week, a 23 May 1967 LAT brief reported that James Neilson would direct from a script written by Blanche Hanalis, who had written the script for The Trouble with Angels, based on Jane Trahey’s 1962 novel, Life with Mother Superior.
       According to a 3 Jul 1967 DV brief, Binnie Barnes and Mary Wickes traveled with filmmakers to seven different cities to audition school girls for the film.
       A production chart in the 21 Jul 1967 DV stated that principal photography had begun earlier that week, on 17 Jul 1967. Shooting was done in Philadelphia, PA, then moved to Santa Fe, NM, by early Aug, according to the 11 Aug 1967 LAT. The 16 Jun 1967 LAT had previously stated that production would also take place in Arizona.
       On 22 Jan 1968, DV noted that a recent sneak preview of the film at the UA Inglewood Theatre in Inglewood, CA, had been well-received. A 3 Apr 1968 world premiere was scheduled to take place in Houston, TX, where Mayor Louis Welch declared the week surrounding the event “Angels Week in Houston,” according to the 29 Mar 1968 DV. The premiere served as a benefit for Houston’s Holy Name Retreat House. Where Angels Go…Trouble Follows! went on to open in New York City and Los Angeles, CA, on 10 Apr 1968. It received mixed reviews. By early 1969, it had grossed $1.4 million in film rentals, the 8 Jan 1969 Var noted.
       Monty Whitney was expected to make his feature film acting debut in the picture, as announced in the 12 Jul 1967 LAT. Alexandra Hay and Wayne Sutherlin were also named as cast members in the 18 Jul 1967 and 25 Jul 1967 issues of DV.