An African American man named House escapes a secret facility where white guards keep black inmates locked up. As he runs away, House finds a young couple in the woods and demands their help, wielding a stolen shotgun. Frightened, the couple leads the escapee to their car. The next day, House’s friend, record producer Jimmy Lait, takes House to the hospital, where House warns him that someone is trying to kill them all. Attempting to explain what happened in between gasps for air, House says he was kidnapped and tortured, but when he loses consciousness, Jimmy returns to his work for a few hours. That night, two of House’s former captors break into his hospital room and murder him, kidnapping Jimmy’s girlfriend, Wendy Kane, on their way out. Panicked, Jimmy talks to police lieutenant Di Nisco, who asks Jimmy to step aside and let the police investigate the case. Undeterred, Jimmy vows to find Wendy. Meanwhile, after arriving at the secret compound where House was once held, Wendy meets the proprietor, Monroe Feather, a white supremacist who proudly describes his plan to rid the United States of African Americans. In Chicago, Illinois, Jimmy seeks out his friend, Jagger Daniels, asking for his help in looking for Wendy. Two of Feather’s white supremacist henchmen arrive in Chicago to kill Jimmy, but Jimmy and Jagger kill them in a shootout. At a laboratory, Feather speaks to Dr. Fortrero, who has developed a poison that can kill African Americans but does no harm to white people. At the same time, Jimmy and Jagger travel to New York City where they meet up with their friend, Mister Keyes, a karate expert. In another shootout with Feather’s men, Jimmy is shot. Keyes and Jagger take Keep, one of the white supremacists, hostage, and while Jimmy gets stitches at the hospital, Jagger calls in three dominatrixes, Princess, Countess, and Empress, to torment Keep until he names Feather and Fortrero, explaining their plans to commit genocide. Keep mentions Washington, DC; Los Angeles, California; and Detroit, Michigan, as cities that Monroe plans to target, so the men decide to split up. In Los Angeles, Jimmy receives instructions from his assistant to wait at a payphone for a call from Wendy. However, as Jimmy picks up the call, two of Feather’s thugs run over the payphone booth with a large truck. Though the men think Jimmy is dead, he sneaks onto the truck and overhears their plan to poison the city’s drinking water. Jimmy throws one of the men out of the cab, jumping off after him, and the driver crashes, dying in the ensuing explosion. Meanwhile, Keyes goes to Washington, DC, where he owns a karate school, and Jagger heads to Detroit. Jimmy calls Jagger and Keyes to inform them that the city water supplies are where Feather’s people intend to spread their poison. Jagger stops Feather’s men at the water plant in Detroit, while Keyes joins forces with Link, a karate instructor, to protect the plant in Washington, DC. Likewise, Jimmy stops Feather’s men at the Los Angeles water plant. Later, as Feather gathers his disciples to announce the mass poisoning, Jimmy and his accomplices meet at an airport and drive a van full of weapons to Feather’s headquarters. Infiltrating Feather’s celebration, Jimmy, Jagger, and Keyes shoot their way through the compound, setting Dr. Fortrero on fire in the process. The men rescue Wendy, and Keyes takes her back to the van while Jagger and Jimmy seek out Feather, attaching an explosive to his getaway car. Feather dies, and Jimmy and Wendy are reunited.