Bob Eller has come to Penang in tropical Asia to escape his tyranical father and unfaithful girl friend in San Francisco. Safari hunter Ramsey Doyle is after the feared "Rumow Satan," or "Devil Tiger," who has killed a number of natives in the nearby villages. Interested in the tiger, Bob decides to join the safari to get his mind off his troubles. After a few days of traveling, the safari arrives at the Brewster rubber plantation, where the tiger was last seen. Mary Brewster, whose husband was killed by the tiger, gives them an account of what happened and insists on accompanying them on the safari, during which they see a leopard and a python fighting. The next day, Bob and Ramsey tell Chinese servant Ah Lee to set the tiger trap. That night, the tiger is lurking outside Mary's tent when a crocodile scares it away. The following morning, Ramsey and Bob are eating breakfast, when a baby elephant is attacked by a panther. The elephant tries to escape, but it is caught in the tiger trap. Ramsey and Bob free the elephant, name her "Sally," and take her with them as they continue. They come across a foot-long lizard, a throw back to the prehistoric "Monitor Lizard." The lizard fights a biturong, but the fight ends in a draw. When Ramsey decides that they should rest for Mary's sake, Bob makes disparaging comments about women. Then a monkey fights with three giant crabs, and a leopard fights a tiger. They enter a village where they learn that the Devil Tiger killed a native twenty-five miles away. A panther and a crocodile then fight. The safari comes to a stream, and as natives cross, a crocodile attacks. Bob jumps in the water and saves Ah Lee. The next day, Ah Lee comes into camp with a bear cub. The mother bear, who has followed her baby, fights with a hyena. Sally gets scared and tries to run away, and Bob, chasing her, is attacked by a python. Mary grabs a rifle and shoots the python, saving Bob's life. He thanks her and they fall in love. Later a tiger attacks, scaring away all the natives except Ah Lee. They realize that it is the Devil Tiger, so they pack up, and as they leave, they see a lion and tiger fighting. They stop again and Mary goes for a swim in a nearby stream. The Devil Tiger attacks a herd of elephants drinking at the stream, who begin to stampede. Mary, Bob and Ramsey climb trees to escape the elephants, but Ramsey's tree topples, and he gets trampled to death. The safari continues, and they see a buffalo fighting a python. After a long hike, they come to a village where the Devil Tiger, who has been stalking them, attacks. Bob shoots it, and Ah Lee says with relief, "Devil Tiger no more."